English | 2022 | ISBN: 1636393497, 978-1636393490 | 175 pages | True PDF | 8.33 MB
MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19-25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner . Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth of the tumor, metastasis, drug resistance, immune system function, as well as angiogenesis. Therefore, exosomes have been explored as diagnostic biomarkers in many cancers. Moreover, exosomes can be used as biological vehicles to deliver different drugs and agents like doxorubicin (DOX), miRNAs, and siRNAs. The present book covers the role of exosomes and micro-RNAs in the pathogenesis and treatment of various diseases.

English | 2022 | ISBN: 1264703325 | 326 pages | EPUB | 5.37 MB
A veteran Silicon Valley insider provides the first comprehensive guide to developing and executing a startup exit strategy—the secret to ultimate entrepreneurial success

English | 2022 | ISBN: 0415409063 | 291 pages | True PDF | 100.71 MB
This book provides an enquiry into the distinguishing traits of Greek and Roman figural imagery. A detailed analysis of a wide range of material conveys an understanding of the figural imagery of classical antiquity as a whole, counterbalancing studies conducted on single genres.

English | 2021 | ISBN: 1784664510, 978-1784664510 | 290 pages | True PDF | 111.08 MB
Using the familiar software Microsoft (R) Excel, this book examines the applications of complex variables. Implementation of the included problems in Excel eliminates the "black box" nature of more advanced computer software and programming languages and therefore the reader has the chance to become more familiar with the underlying mathematics of the complex variable problems.

English | 2022 | ISBN: 0197637183 | 201 pages | True PDF EPUB | 9.31 MB
What is evil? Who does evil things? Who is evil? How do you know? Whether in response to witnessing mass suffering or feeling the sting of personal injustice, people confidently apply the "evil" label to perpetrators and the harm that they inflict, yet evil's essence remains mysterious to many.

English | 2021 | ISBN: 1577152220, 978-1577152224 | 275 pages | True PDF | 2.56 MB
This easy-to-understand handbook teaches essential math concepts using real-life examples so you can confidently apply math skills in everyday situations such as personal finance, cooking, home repair, and shopping.

English | 2022 | ISBN: 0062939971 | 464 pages | True EPUB | 32.17 MB
The stylish, wild story of the marriage of Dennis Hopper and Brooke Hayward—a tale of love, art, Hollywood, and heartbreak

English | 2022 | ISBN: 1032135255, 978-1032135250 | 157 pages | True PDF | 8.52 MB
This book considers event-triggered scheme as a transmission protocol to negotiate information exchange in resilient control for networked control systems (NCS) via a robust control algorithm to regulate the closed loop behaviour of NCS in the presence of mismatched uncertainty with limited feedback information for both linear/nonlinear systems.

English | 2022 | ISBN: 0197620825 | 201 pages | True PDF EPUB | 11.52 MB
Today's societies require research approaches that are creative, sensitive to cultural and contextual diversity, rooted in engagement and critical dispositions, and situated within local contexts. Action research and evaluation are inquiries into and about human lives. Both modes generate actionable data in specific contexts to facilitate positive social change and to further social justice.

English | 2022 | ISBN: 1032312963| 259 pages | True PDF | 2.73 MB
This is an important book. Ethics is not an easy topic, and arguably the ethics of IT is less so—not leastdue to its potential for developing and evolving in ways that are either unforeseen or unimaginable . . . . Use this book as a practical resource, an informative and educational source of material in developing expertise, but also as an invaluable toolkit to support practical application of ethical thinking.