Steroid hormone antagonists not only form excellent tools to study various aspects of the receptor structure and function but they are also important in diagnostic and clinical medicine. Antagonists for all classes of steroid hormones are actually used in the treatment of a wide array of disorders. Medical treatment has now become possible in cases where surgery used to be the only available therapy.
The present volume groups together latest conceptual developments and ongoing designs for antagonists in all groups of steroid hormones by some of the leading authorities actually involved in their respective fields. At the biochemical and pharmacological level, very dramatic advances have been made in the area of antimineralocorticoids. For the first time, a specific probe for the mineralo-receptor has been marketed and this book presents the only available review in this area.
In this day and age of specialization and literature explosion, it is often a herculean task to keep abreast of developments even in one's own particular field. This book may be used as a source of material that individuals involved constantly in their routine work would not otherwise read. Newcomers may use this volume as a starting point for backtracking the history and development of antisteroid research. It is hoped that cross fertilization of ideas developed in different areas will lead to even greater progress when readily available under a single cover.
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