For each disease, the authors provide a commentary to help select the best of all antimicrobial choices. Drug descriptions cover all antimicrobial agents available today and include complete information about dosing regimens.
TOPICS INCLUDE
Antimicrobial Therapy by Clinical SyndromesAntimicrobial Therapy for NeonatesChoosing Among[list]AntibioticsAntifungal AgentsAntiviral AgentsAntiparasitic Agents
Oral Step-down Therapy for Serious InfectionsPrevention of Symptomatic InfectionApproach to Antibiotic AllergiesAntibiotic Stewardship
New in the 28th Edition
Updated recommendations on acute hematogenous osteomyelitis, based on newly published guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America, including information on a decrease in the incidence of MRSA infections, allowing the recommendation of cefazolin, again, in empiric therapy for most pediatric bone infectionsUpdated recommendations on influenza treatment and prophylaxis, reflecting American Academy of Pediatrics guidance for 2021–2022Ceftazidime/avibactam now preferred over fluoroquinolones for treatment of Klebsiella pneumoniae carbapenemase–producing enteric bacilli, if susceptibleCefiderocol, a new iron-binding siderophore cephalosporin class, recently approved in adults for treatment of many drug-resistant pathogens, particularly Acinetobacter, Stenotrophomonas, and Pseudomonas; under study in childrenNew dosing for posaconazole suspension formulationNew approaches to mucormycosisAdded baloxavir for children 12+ years oldOnline updates of COVID-19 therapies once emergency use authorization in children at

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