Detection of pathogenic infections in neurological disorders through recycling of gene expression data
English | 2021 | ISBN: 3736974094 | 143 Pages | PDF (True) | 10 MB
For increasing the knowledge about small RNA an online platform was built in this thesis, homogenizing the analysis of sequencing data from over 4,000 samples collected in different laboratories worldwide from various organisms. Consequentially, tissue and disease specific biomarkers were detected and evidence was found for bacterial and viral infections of the sequenced tissues. This motivated the development of an algorithm for analyzing non-host RNA sequencing reads for detecting pathogenic abundance in the host. Focusing on neurological diseases, bacterial presence is suggested in brains of dementia patients. The platform and the algorithm can help scientists to add important leads to their own studies. In dieser Arbeit wurde eine Online-Plattform für small RNA entwickelt, die die Analyse der Sequenzierungsdaten von über 4.000 weltweit gewonnenen Proben verschiedener Organismen homogenisiert. Mit ihr wurden gewebe- und krankheitsspezifische Biomarker gefunden, sowie Hinweise auf bakterielle und virale Infektionen der sequenzierten Gewebe. Dies motivierte die Entwicklung eines Algorithmus für die Analyse von Nicht-Wirts-RNA-Sequenzierungsdaten zum Detektieren von Pathogenen. Bei einer Fokussierung auf neurologische Erkrankungen wurde bakterielle Präsenz im Gehirn von Demenzpatienten detektiert. Die Plattform und der Algorithmus können der Wissenschaft behilflich sein, neue Studien mit wichtigen Informationen zu verbessern.

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